Results of the SILAC-MS analysis.

<p>(A) Histograms showing the frequency of the SILAC log₂ ratios of proteins in cytoplasmic (top panel) and nuclear (bottom panel) fractions from DENV-2 (DV2) and mock infected cells. The log₂ ratios were grouped into bins. The number of ratios per bin is shown on the <i>y</i>-axis. The cut-off points for 1.5 and 2 fold (log₂ values of ± 0.585 and 1 respectively) increases and decreases from the median values are shown. (B) A Venn diagram showing the number of proteins that were detected either in both the cytoplasmic and nuclear fractions or exclusively in each fraction. (C) A scatter plot showing the nuclear (<i>y</i>-axis) and cytoplasmic (<i>x</i>-axis) SILAC log₂ DV-2/mock ratios for the 1361 proteins that were identified and quantified in both fractions. The values for each protein are shown as a red diamond.