Mutation of CFTR worsens lung infection, alveolar neutrocytosis, and thrombocytopenia.

<p>Wildtype and <i>F508del</i> mice were intratracheally challenged with <i>E. coli</i> (10⁷ cfu) and killed at 4 h. BAL was performed to culture bacteria and count neutrophils. Blood was withdrawn to count platelets. <b>A</b>. BAL <i>E. coli</i> counts. <b>B</b>. BAL neutrophil numbers. <b>C</b>. Blood platelet counts. Values are presented as mean ± SD. Sample size (each dot represents one sample) and <i>P</i> values are indicated in each panel.