CFTR inhibition by MalH-2 affects blood platelet counts, plasma MIP-2 levels, and parameters of lung inflammation in <i>E. coli</i> pneumonia.

<p>Wildtype mice were divided into two groups to receive an ip of either PBS or MalH2 (3 mg/kg), then intratracheally challenged with <i>E. coli</i> (10⁷ cfu). At 4 h, mice were killed to collect plasma and BAL and measure the relevant parameters. <b>A</b>. Blood platelet counts. <b>B</b>. Plasma MIP-2 levels. <b>C</b>. BAL neutrophils. <b>D</b>. BAL MIP-2 levels. Values are presented as mean ± SD. Sample size and <i>P</i> values are indicated in each panel.