Demographic and clinical characteristics of HCs, CIS patients, all MS patients and MS subtypes patients.

<p>Data are expressed as median and range (in brackets). There were no statistically significant differences between HCs and MS patients in age (p = 0.721; 0.153) or sex (p = 0.148; 0.332). § Mann-Whitney <i>U</i> test between CIS and MS patients. * Kruskal Wallis one-way analysis of variance among MS patients.</p><p>HCs = healthy controls subjects; CIS = clinically isolated syndrome; MS = multiple sclerosis; MS Subtypes: RR = relapse remitting; SP = secondary progressive, PP = primary progressive.