Parametric Response Maps creation process.

<p>1) comparison of the rCBV values of a ROI placed on the normal white matter between the baseline and the time point under examination; 2) Classification of increased, decreased and unchanged differences values in the tumor area on the basis of the previously determined thresholds; 3) Chromatic representation of the difference map obtained by the subtraction of the baseline map from the time point one. Red voxels indicate an increase of rCBV, blue a decrease and black voxels are unchanged.