Growth and survival of mice.

<p>(A) Photograph of a two-week-old <i>ZFP521^Δ/Δ</i> mouse and its <i>ZFP521^+/+</i> littermate. (B) Growth curve of mice. Mice were housed singly, weighed weekly and. euthanized at a predetermined humane endpoint. ▪, <i>ZFP521^+/+</i> mice; ▴, <i>ZFP521</i>^+/Δ mice; ▾, <i>ZFP521</i>^Δ/Δ mice. Each point with bar represents mean ± SD, n = 12. *, P<0.001, compared to <i>ZFP521^+/+</i> mice. (C) Kaplan-Meier survival curves of mice. ▪, <i>ZFP521^+/+</i> mice; ▴, <i>ZFP521^+/Δ</i> mice; •, <i>ZFP521^Δ/Δ</i> mice. <i>ZFP521^+/+</i> mice, n = 114; <i>ZFP521^+/Δ</i> mice, n = 181; <i>ZFP521^Δ/Δ</i> mice, n = 48. *, P<0.001, in comparison with <i>ZFP521^+/+</i> mice. Mice were monitored daily and euthanized at a predetermined humane endpoint.