Shp2 CKO mice develop severe colitis.

<p><b>A</b>: Body weight of 2-, 3-, or 4-week-old control (male, <i>n</i> = 23, 26, and 27, respectively; female, <i>n</i> = 22, 24, and 22, respectively) or Shp2 CKO (male, <i>n</i> = 17, 20, and 16, respectively; female, <i>n</i> = 15, 15, and 13, respectively) mice is shown in the left panel. Data are means ± SE. *<i>P</i><0.05, ***<i>P</i><0.0001 (Welch's <i>t</i> test). N.S., not significant. Representative photographs of control and Shp2 CKO mice at 5 weeks of age are shown in the right panel. Scale bar, 1 cm. <b>B</b>: Disease activity index (DAI) for colitis in control (<i>n</i> = 19) and Shp2 CKO (<i>n</i> = 11) mice at 4 to 5 weeks of age. Bars indicate median scores. ***<i>P</i><0.0001 (Wilcoxon rank-sum test). <b>C</b>: Survival rates of control (<i>n</i> = 19) and Shp2 CKO (<i>n</i> = 17) mice.