Chronic Rb1 treatment improved central leptin signaling in obese mice fed a HF diet for 16 weeks.

<p>The phosphorylation of STAT3 (A) and FOXO1 (B) in the mediobasal hypothalamus 1 hour after the icv injection of leptin or saline in mice fed a LC diet and obese mice fed a HF diet for 16 weeks with or without chronic treatment of Rb1 (n = 6–8). *<i>p</i><0.05 vs. (vehicle + saline) group; ^#<i>p</i><0.05 vs. (vehicle + Leptin) group; +p<0.05 vs. (Rb1 + saline) group. Data are presented as mean ± SEM.