Clodrolip enhances BCC growth in <i>Ptch^flox/floxERT2^+/−</i> mice.

<p>(A) H&E stainings of paraffin-sections derived from BCC-bearing skin of liposome- or clodrolip-treated <i>Ptch^flox/floxERT2^+/−</i> mice. (B) Relative tumor areas of H&E-stained BCC-bearing skin samples of liposome- or clodrolip-treated <i>Ptch^flox/floxERT2^+/−</i> mice. The mean value of the liposome-treated controls was normalized to 1. Left panel shows the mean value (+SEM) of all liposome- and clodrolip-treated animals **<i>P</i><0.01; right panel shows the mean value (+SEM) of all liposome-treated animals in comparison with 2 clodrolip-treated mice (mouse 2 and mouse 3 in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093555#pone-0093555-t001" target="_blank">Table 1</a>), in which the phagocytic cells have been very efficiently depleted (due to the small sample size, statistical analysis was omitted). (C) Viability/metabolic activity of the BCC cell line ASZ001 after treatment with PBS, liposomes or clodrolip. Mean value of the PBS-treated controls was set to 100%. **<i>P</i><0.01.