Kaplan-Meier curves for overall survival (OS) in GBM according to plasma IGFBP-2 levels after postperative radiotherapy plus chemotherapy.

<p>(A) GBM patients with high plasma IGFBP-2 (>627.5 ng/ml) had a significantly worse OS than did GBM patients with low plasma IGFBP-2 (<627.5 ng/ml; P<0.001).(B) In GBM patients older than 60, high plasma IGFBP-2 (>687 ng/ml) was associated with significantly shorter OS (P<0.001). (C) In GBM patients younger than 60, plasma IGFBP-2 levels were not associated with OS.