ACE genotype determines serum ACE concentration and activity.

<p>Serum ACE concentration, activity and genotype was determined as mentioned earlier (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093719#pone-0093719-g003" target="_blank">Figs. 3</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093719#pone-0093719-g001" target="_blank">1</a>). ACE concentration (<b>A</b>) and activity (<b>B</b>) in patients with different ACE genotypes (insertion, II, <i>n</i> = 28; deletion, DD, <i>n</i> = 52 and heterozygotes, ID, <i>n</i> = 71) are shown. The boxes indicate the interquartile range with median; whiskers are the minimum and the maximum values. Significant differences (1 way ANOVA, Bonferroni post-hoc test) are labelled by asterisks (NS, not significant).