MAL3-101 treatment in an MCC xenotransplantation model demonstrated induction of apoptosis and reduced tumor growth.

<p>WaGa cells embedded in MatriGel were injected s.c. in NOD.CB17-<i>Prkdc^scid</i>/NCrHsd mice. Intraperitoneal injection of MAL3-101 (40 mg/kg) was started (arrow) on day 17 when the tumor volume had reached approximately 100 mm³ and was repeated every second day. (A) Mean values (± SEM, N = 6) of the tumor volume are depicted in the graph. The p-value was calculated using the 2-way ANOVA statistical test. (B) Representative macroscopic photographs depict the respective tumors at day 38. (C) IHC for cleaved caspase III in FFPE tumors excised on day 38 indicating caspase III dependent apoptosis induction in the MAL3-101 treated group compared to control group. The depicted scale bar measures 20 μm.