Cranial irradiation alters myeloid cell population over time.

<p><b>A.</b> 10⁺ cells (ANOVA; <i>F_(3,12) = 12.07, ^★★★p = 0.0006</i>) at 7 (Tukey’s HSD; *<i>p<0.05</i>) and 14 (Tukey’s HSD; **<i>p<0.01</i>) days post irradiation. The percentage of CD11b⁺ cells returned to sham levels by day 28 (Tukey’s HSD; <i>p>0.05</i>). <b>B.</b> Overall, cranial irradiation induced a significant increase in the percentage of CD11b⁺F4/80⁺ macrophages at 7 days (ANOVA; <i>F(3,12) = 4.048, ^★p = 0.0335</i>; Tukey’s HSD; *<i>p<0.05</i>). <b>C.</b> Concomitant with the radiation induced increase of percentage of F4/80⁺ macrophages, we observed a trend for decreased F4/80⁻ stained cells. <b>D.</b> Representative plots showing the 10 Gy radiation induced shift in the percentage of CD11b⁺ cells that stained for F4/80 as a function of time. Average proportion of F4/80⁺ is given.