Effects of embelin on cell proliferation and apoptosis.

<p>(A), Expression of PCNA, Ki67, caspase-3, and PARP in tumor tissues. Immunohistochemistry was performed to measure the expression of PCNA, Ki67, active caspase-3 and PARP in tumor tissues isolated from control and embelin-treated mice. (B), Quantification of TUNEL positive cells. Apoptosis was measured by TUNEL assay. Data represent the mean ± S.D. * = significantly different from control, P<0.05. (C), Effects of embelin on markers of cell proliferation and apoptosis. Western blot analysis was performed to measure the expression of PCNA, Ki67, caspase-3 and PARP in tumor tissues. The β-actin was used as a loading control.