Distribution of average histopathology score.

<p>Kidney sections from the mice that underwent sham operation or bi-lateral renal ischemia –reperfusion were stained with hematoxilin-eosin (as represented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0093297#pone-0093297-g001" target="_blank">Figure 1</a>). These sections were evaluated in a semi-quantitative manner for the signs of tissue injury. Degeneration, necrosis and vacuolation were not detected in the sham-operated animals while they increased in the kidneys with ischemia-reperfusion. Morphological signs of kidney injury progressively accumulated in accordance with reperfusion time. D/N = degeneration/necrosis score; Vac = vacuolation score.