<p><b>A</b>) Day 21 lungs were stained with picrosirius red to show collagen deposition. Bar is 500 μm. <b>B</b>) The percentage area stained with picrosirius red was quantified as a percentage of the total area of the lung. Significance was determined by ANOVA within treatment groups and t-test when comparing C57BL/6 and <i>Apcs<sup>-/-</sup></i> mice. *p<0.05. (n = 4-6 mice per group).</p
Subsequently, mice were euthanized and lungs were examined histopathologically as described in Mater...
Bleomycin treatment produced dose-dependent changes in lung collagen content and in several measurab...
<p>A) NY1DD SCD mice, as compared to appropriate strain (C57Bl/6) and age-matched mice, demonstrate ...
<p>Collagen (green) visualized by picrosirius staining in three slices of the left lung lobe (upper ...
<p>A. H&E-stained lung sections. Representative bright-field micrographs of H&E-stained lung section...
<p>Representative micrographs (x200) with Masson’s trichrome staining of paraffin lung sections (A),...
<p>Animals were treated with 0.1 mg/kg bleomycin (n = 9) or vehicle (n = 5) on six consecutive days ...
<p>(<b>A</b>) Photomicrographs of lung parenchyma stained with Sirius Red from animals in the C, SIL...
<p>a. Accumulation of collagen in the lung of w/t or MPO k/o mice. Mean ± SEM (n = 6 mice/group). *p...
<p>Collagen content in mouse lungs 8 days (<b>A-D</b>), 14 days (<b>E-H</b>) and 21 days (<b>I-L</b>...
<p>(A) IV AFSC injection was administered during either the acute period, 2 hours post-bleomycin inj...
<p>Data are shown as means±STDEV. One-way ANOVA (Two-Way repeated measures ANOVA for MRI-results) wi...
<p>(<b>A</b>) On day 21 after bleomycin treatment, lungs from control sera or anti-asialo GM1 treate...
<p>All data are shown as means ± STDEV. A) Relative body weight and time point of death during the s...
<p>(<b>A</b>) Schematic illustration of the experimental design. (<b>B</b>) At day 28 post bleomycin...
Subsequently, mice were euthanized and lungs were examined histopathologically as described in Mater...
Bleomycin treatment produced dose-dependent changes in lung collagen content and in several measurab...
<p>A) NY1DD SCD mice, as compared to appropriate strain (C57Bl/6) and age-matched mice, demonstrate ...
<p>Collagen (green) visualized by picrosirius staining in three slices of the left lung lobe (upper ...
<p>A. H&E-stained lung sections. Representative bright-field micrographs of H&E-stained lung section...
<p>Representative micrographs (x200) with Masson’s trichrome staining of paraffin lung sections (A),...
<p>Animals were treated with 0.1 mg/kg bleomycin (n = 9) or vehicle (n = 5) on six consecutive days ...
<p>(<b>A</b>) Photomicrographs of lung parenchyma stained with Sirius Red from animals in the C, SIL...
<p>a. Accumulation of collagen in the lung of w/t or MPO k/o mice. Mean ± SEM (n = 6 mice/group). *p...
<p>Collagen content in mouse lungs 8 days (<b>A-D</b>), 14 days (<b>E-H</b>) and 21 days (<b>I-L</b>...
<p>(A) IV AFSC injection was administered during either the acute period, 2 hours post-bleomycin inj...
<p>Data are shown as means±STDEV. One-way ANOVA (Two-Way repeated measures ANOVA for MRI-results) wi...
<p>(<b>A</b>) On day 21 after bleomycin treatment, lungs from control sera or anti-asialo GM1 treate...
<p>All data are shown as means ± STDEV. A) Relative body weight and time point of death during the s...
<p>(<b>A</b>) Schematic illustration of the experimental design. (<b>B</b>) At day 28 post bleomycin...
Subsequently, mice were euthanized and lungs were examined histopathologically as described in Mater...
Bleomycin treatment produced dose-dependent changes in lung collagen content and in several measurab...
<p>A) NY1DD SCD mice, as compared to appropriate strain (C57Bl/6) and age-matched mice, demonstrate ...