<i>ASIC2−/−</i> hippocampal neurons have reduced acid-evoked currents.

<p><i>A</i>, Representative pH 5-evoked currents from wildtype and <i>ASIC2−/−</i> cultured mouse hippocampal neurons. <i>B</i>, The ratio of pH 6.8-evoked to pH 5-evoked current amplitudes as a measure of pH sensitivity (<i>n</i> ≥9; *<i>P</i><0.01). <i>C</i>, Superimposed pH 5-evoked currents from hippocampal neurons of the indicated genotypes (vertical scale bar: 1 nA wildtype and 0.58 nA <i>ASIC2−/−</i>). <i>D</i>, Mean time constants (τ) of desensitization (<i>n</i> ≥11; *<i>P</i><0.05). <i>E</i>, Mean current amplitude density evoked by pH 5 (<i>n</i> ≥11; *<i>P</i><0.01).