CCR6-deficient mice are more susceptible to pneumococcal meningitis.

<p>CCR6-deficient mice were more strongly affected from a clinical perspective by infection with <i>Streptococcus pneumoniae</i> than wild type controls. This was reflected (A) in increased clinical scores and (B) mortality. (C) CSF pleocytosis was lower in infected CCR6-deficient animals 24 h and 48 h after infection. (D) This was associated with higher brain bacterial titers at the time of initiation of antibiotic therapy (24 h after infection). (*) p<0.05 compared with infected wild type animals. Number of animals: 24 h: <i>Ccr6</i>^−/− n = 12, WT n = 12; 48 h: <i>Ccr6</i>^−/− n = 12, WT n = 13.