Course of symptoms during pre-dialysis care.

<p>The course of the total number of symptoms is presented for the total population (A) and stratified by the type of endpoint reached (combined poor health outcome; dialysis/transplantation/death, or end of follow-up/other endpoint, B). The black and grey dots indicate the mean and the error bars indicate the standard error of the mean (SEM). The time in months before reaching an endpoint is presented on the x-axis (−12 means that the measurement was 7–12 months before reaching an endpoint, −18 means 13–18 months etc). On the y-axis, the mean (SEM) total number of symptoms is presented, which can range from 0 to 12.