<p>(A) Mean ± S.E.M. block of sorbitol uptake by chymotrypsin treatment on indicated parental lines and progeny clones (black and gray bars, respectively). (B) Logarithm of odds (LOD) scores from a primary scan of QTL associated with PSAC inhibition. The peak at the 5′ end of chromosome 3 contains the two <i>clag3</i> genes. The <i>P</i> = 0.05 significance threshold (dashed horizontal line) was calculated from 1000 permutations. Inset shows results from a secondary scan for additional QTL after controlling for the <i>clag3</i> locus. No other loci reached the <i>P</i> = 0.05 threshold (dashed horizontal line). (C) Osmotic lysis kinetics for indicated parasites after selection for expression of a specific <i>clag3</i> gene. Black and red tr...
A schematic representation in scale of the chymase locus from a panel of placental mammals. This is ...
Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiab...
<p>A, B and C: Maps of the three regions of similarity between λ and MG1655 used in this study. Anti...
<p>(A) Multiple sequence alignment of an extracellular loop on indicated CLAG3.1 and CLAG3.2 sequenc...
<p>(A) Immunoblots showing CLAG3 hydrolysis in HB3 and Dd2 parasites by chymotrypsin (“Ch”), trypsin...
Background.: Many genes of the malaria parasite Plasmodium falciparum show clonally...
The product of the Plasmodium falciparum genes clag3.1 and clag3.2 plays a fundamen...
<p>Peptides are listed by their standard abbreviations, unknowns are abbreviated as Ukn, and 6PGn in...
<p>Wild-type (ΔKu80) = wild-type parasites. A) Design of ΔCDPK3-TOXOY72 cosmid construct, whereby do...
SummaryDevelopment of malaria parasites within vertebrate erythrocytes requires nutrient uptake at t...
The plasmodial surface anion channel mediates uptake of nutrients and other solutes into erythrocyte...
<p>(A) Schematic representation of the TcCRT genomic locus in TcCRT+/– parasites (B) PCR analysis ca...
Background: Elevated parasite biomass in the human red blood cells can lead to increased malaria mor...
Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiab...
<p>(A) Blue Native PAGE analysis of FLAG IP eluates obtained from a FLAG-tagged CLAG3 parasite (HB3<...
A schematic representation in scale of the chymase locus from a panel of placental mammals. This is ...
Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiab...
<p>A, B and C: Maps of the three regions of similarity between λ and MG1655 used in this study. Anti...
<p>(A) Multiple sequence alignment of an extracellular loop on indicated CLAG3.1 and CLAG3.2 sequenc...
<p>(A) Immunoblots showing CLAG3 hydrolysis in HB3 and Dd2 parasites by chymotrypsin (“Ch”), trypsin...
Background.: Many genes of the malaria parasite Plasmodium falciparum show clonally...
The product of the Plasmodium falciparum genes clag3.1 and clag3.2 plays a fundamen...
<p>Peptides are listed by their standard abbreviations, unknowns are abbreviated as Ukn, and 6PGn in...
<p>Wild-type (ΔKu80) = wild-type parasites. A) Design of ΔCDPK3-TOXOY72 cosmid construct, whereby do...
SummaryDevelopment of malaria parasites within vertebrate erythrocytes requires nutrient uptake at t...
The plasmodial surface anion channel mediates uptake of nutrients and other solutes into erythrocyte...
<p>(A) Schematic representation of the TcCRT genomic locus in TcCRT+/– parasites (B) PCR analysis ca...
Background: Elevated parasite biomass in the human red blood cells can lead to increased malaria mor...
Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiab...
<p>(A) Blue Native PAGE analysis of FLAG IP eluates obtained from a FLAG-tagged CLAG3 parasite (HB3<...
A schematic representation in scale of the chymase locus from a panel of placental mammals. This is ...
Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiab...
<p>A, B and C: Maps of the three regions of similarity between λ and MG1655 used in this study. Anti...