11-Dehydrocorticosterone [11-DHC) stimulates insulin secretion under basal glucose conditions in islets isolated from DEX rats.

<p><i>A</i>: Insulin secretion in response to incubation with 5.6 mmol/l glucose with or without 11-DHC or carbenoxolone in islets isolated from DEX and CTL rats (<i>n</i> = 10 wells). <i>B</i>: Insulin secretion in response to incubation with 16.7 mmol/l glucose with or without 11-DHC or carbenoxolone in islets isolated from DEX and CTL rats (<i>n</i> = 10 wells). Data are the mean ± SEM. *** <i>p</i><0.001 <i>vs.</i> CTL. ^†<i>p</i><0.05 <i>vs.</i> 5.6 mmol/l glucose. ^‡<i>p</i><0.05 <i>vs.</i> 5.6 mmol/l glucose plus 100 nmol/l 11-DHC.