<p>a.) Disc diffusion assay was performed using discs containing 20 μmol diamide. The zone of inhibition of <i>Mtb</i>:ΔRv2745c (red bar) is significantly larger when compared to both <i>Mtb</i> (blue bar) and <i>Mtb</i>:ΔRv2745c (comp) (green bar) indicating that the isogenic mutant is more susceptible to redox stress. n = 3. *p<0.001 b.) OD graph of diamide treated cultures. In the initial stages of treatment, there is no significant difference in growth between the different groups.</p
<p>(A and B) Susceptibility of WT and mutant strains to Zn(II) as assessed by disk diffusion assay. ...
<p>A. Dose-response curves in low-throughput <i>Mtb</i> DHFR enzyme assay. NC00094221 (chemical stru...
A mutant, T7, highly sensitive to oxidative stress as caused by diamide was isolated from a Mycobact...
<p>mBBr, monobromobimane; IAM, iodoacetamide; NEM, <i>N</i>-ethylmaleimide; CDNB, 1-chloro-2,4-dinit...
<p>**<i>P</i>≤0.01 versus wild type for the mutant.</p>a<p>The values are mean±SD for three independ...
<p>Venn diagrams describe the extent of overlap between gene-expression upon diamide treatment in <i...
<p>Venn diagrams describe the extent of overlap between gene-expression upon diamide treatment in <i...
<p>(A) and (B) DR0865 binding to p2523 and p2284 as the concentration of DR0865 increased. (C) Wild-...
Representative pictures of agar plates showing the size of inhibition zones for WT Pa, ROS-sensitive...
<p>Genes induced and repressed by functional category at 60 minutes post-diamide treatment in the is...
<p>The resistance to dioxygen was assayed by counting colony-forming units of bacterial cells suspen...
<p>(A) Phenotype of the wild-type (resistant), the <i>katA</i> mutant (highly sensitive), and the <i...
<p>A, B: host strain AD/pABC3; C, D: AD/CaCDR1; and E, F: AD/CaMDR1 at pH 6.8. A, C, E: paper disks ...
<p>**<i>P</i>≤0.01 versus wild type for the mutants.</p>a<p>The values are mean±SD for three indepen...
<p>A) The Kirby Bauer disc diffusion assay was performed with different antibiotics (CA30, CPM30, CI...
<p>(A and B) Susceptibility of WT and mutant strains to Zn(II) as assessed by disk diffusion assay. ...
<p>A. Dose-response curves in low-throughput <i>Mtb</i> DHFR enzyme assay. NC00094221 (chemical stru...
A mutant, T7, highly sensitive to oxidative stress as caused by diamide was isolated from a Mycobact...
<p>mBBr, monobromobimane; IAM, iodoacetamide; NEM, <i>N</i>-ethylmaleimide; CDNB, 1-chloro-2,4-dinit...
<p>**<i>P</i>≤0.01 versus wild type for the mutant.</p>a<p>The values are mean±SD for three independ...
<p>Venn diagrams describe the extent of overlap between gene-expression upon diamide treatment in <i...
<p>Venn diagrams describe the extent of overlap between gene-expression upon diamide treatment in <i...
<p>(A) and (B) DR0865 binding to p2523 and p2284 as the concentration of DR0865 increased. (C) Wild-...
Representative pictures of agar plates showing the size of inhibition zones for WT Pa, ROS-sensitive...
<p>Genes induced and repressed by functional category at 60 minutes post-diamide treatment in the is...
<p>The resistance to dioxygen was assayed by counting colony-forming units of bacterial cells suspen...
<p>(A) Phenotype of the wild-type (resistant), the <i>katA</i> mutant (highly sensitive), and the <i...
<p>A, B: host strain AD/pABC3; C, D: AD/CaCDR1; and E, F: AD/CaMDR1 at pH 6.8. A, C, E: paper disks ...
<p>**<i>P</i>≤0.01 versus wild type for the mutants.</p>a<p>The values are mean±SD for three indepen...
<p>A) The Kirby Bauer disc diffusion assay was performed with different antibiotics (CA30, CPM30, CI...
<p>(A and B) Susceptibility of WT and mutant strains to Zn(II) as assessed by disk diffusion assay. ...
<p>A. Dose-response curves in low-throughput <i>Mtb</i> DHFR enzyme assay. NC00094221 (chemical stru...
A mutant, T7, highly sensitive to oxidative stress as caused by diamide was isolated from a Mycobact...