Heat-map simulations of the (scaled) two-clone model (S1.35)–(S1.40) for a low value of T-cell killing efficacy (day cell)⁻¹.

<p>The 30-year time evolution of the scaled level of -autoreactive T-cells: (A1–A4), -autoreactive T-cells: (B1-B4), -cells: (C1–C4), -reactive autoantibodies: (D1–D4) and -reactive autoantibodies: (E1–E4). The colors in these panels represent the levels of these quantities according to the color-bars on top of each column. The simulations are performed over the following ranges of T-cell avidities: (A1–E1), (A2–E2) (A3–E3) and (A4–E4), where inequality (2) is satisfied. Notice here that panels (A1–A4) and (B1–B4) also depict - and -autoreactive T-cell avidity maturation, respectively, during the time-course of the autoimmune attack. Because is too small, the magnitude of -cell loss is minimal, but is sufficient to elevate the level of circulating T-cells.