Effect of collagen coating on cell proliferation in melanoma.

<p>500/well were plated on 96 collagen coated multiwells (IgR39 and IgR37) and submitted to 1 kPa osmotic pressure for 6 days. Cell growth was evaluated as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094229#pone-0094229-g002" target="_blank">Fig.2</a>. The graph shows that the presence of collagen slows cell growth both in primary (IgR39) and metastatic (IgR37) cells but the effect is much stronger for primary cells. Additional osmotic pressure does not significantly alter the results. Statistically significant results, according to the KS test (), are denoted with *.