Dexamethasone acts differentially on human glioma cells.

<p>(<b>A</b>), Dexamethasone (DEXA) promotes human T98G and U251 glioma growth. Human T98G and U251 glioma cells were cultured at various concentrations of DEXA and cell viability was determined with the MTT assay. (<b>B</b>), Dexamethasone reduces human U87 glioma cell growth solely at high concentrations. Right, representative images of U87 glioma cells treated with low and high dosage of DEXA. Scale bar represents 200 μm. (<b>C</b>), Human embryonic kidney cells are growth sensitive to increasing DEXA concentration. (<b>D</b>), Human primary astrocytes are resistant to various DEXA concentrations. Cell growth is given in relation to untreated controls. Quantification is given for n = 12. Values are given as mean ± S.D. with controls set as 100%. Differences were considered statistically significant with p<0.05 (asterisks, two-sided Student's <i>t</i>-test).