Induction of apoptosis by DOX-PCL₆₃-b-PNVP₉₀ micelles.

<p>The effect of free DOX or, DOX-PCL₆₃-b-PNVP₉₀ on the induction of apoptosis in parental (A) and doxorubicin resistant (DOX-R) (B) tumor cells was quantified by flow cytometric analysis of Annexin V FITC staining in tumor cells following 18 h treatment with indicated drugs. The lower left (LL) quadrant represents live/healthy cells, the lower right (LR) quadrant represents early apoptosis, and the upper right (UR) represents cells in late apoptosis, while the upper left (UL) represents the percent DOX uptake. The percentage of cells undergoing early or, late apoptosis is indicated in the respective quadrate. Data shown are mean ± SD, n = 3.