Differences in HIV⁺ vs. HIV⁻ scatter plots of DSST/protein abundance correlation analyses results for four salivary proteins of interest.

<p>(A–D) Scatter plots showing the correlation of specific salivary protein abundance values against measured DSST scores in HIV⁺, heroin dependent individuals. The proteins include IL1RA (interleukin-1 receptor antagonist), CANX (calnexin), VCP (valosin-containing protein), and UBA1 (ubiquitin-like modifier-activating enzyme 1). All proteins, except for IL1RA, show significant direct correlation of DSST with salivary protein abundance at <i>P-</i>value<0.05. (E–H) Scatter plots showing the same comparison except against HIV⁻ heroin dependent individuals; however, no perceived correlation is observed, i.e., all p-values are well above 0.05. The linear regression is shown by a red line, and the Pearson product-moment correlation score (<i>r</i>) and Benjamini-Hochberg corrected <i>P</i>-values are indicated in the inlay boxes.