Asymptomatic versus patient paired volcano plot to determine differentially expressed genes.

<p>The <i>x</i>-axis shows the paired-sample t-test log₂ fold change of asymptomatic versus symptomatic patients, whereas the <i>y</i>-axis shows the −log₁₀ of the paired t-test p-values of asymptomatic versus symptomatic patients. Each dot represents a gene and the dot color depicts the gene's expression as shown by the standard deviation (SD) of the paired t-test log₂ fold change, e.g. shades of blue for less than or equal to −1 SD, grey for between −1 SD and +1 SD, and red for greater than or equal to +1 SD. A total of 345 genes were differentially expressed at more than 2 and less than −2 linear fold changes (p<0.01) and were considered statistically significant.