Typical desialylated N-glycan profiles from total serum protein and N-glycan values differ significantly among healthy control, gastric ulcer and gastric cancers.

<p>(A) The three panels (from top to bottom) are typical serum N-glycan profiles from healthy control, gastric ulcer and gastric cancers. Nine major peaks can be identified. The structures of the N-glycan peaks are shown below the chart. Levels in peaks 5 and 9 are elevated (up arrows), and levels in peaks 2, 3, 4, 6, 7 and 8 are decreased (down arrows) in gastric cancer compared with that in healthy and disease controls. Peaks 1, 2, 3, 4, 6 and 7 are core-fucosylated glycans. (B) The value of peak9 (branching α-1,3-fucosylated triantennary N-glycan, NA3FB) is elevated sequentially from healthy control, gastric ulcer to gastric cancer (P<0.001), Error bars represent 95% confidence intervals (95%CI) for means. (C) The value of sumfuc is decreased in gastric cancer (P<0.001). Sumfuc indicates the total abundance of core-fucosylated structure glycans (peaks 1, 2, 3, 4, 6 and 7). Error bars represent 95%CI for means.