Cellular proliferation is decreased in LV-shRNA-ADAMTS-1 transduced vessels.

<p><b>A</b>) is representative sections after Ki-67 staining at the venous stenosis of the LV-shRNA-ADAMTS-1 (<b>LV</b>) and control shRNA (<b>C</b>) at day 7. Nuclei staining brown are positive for Ki-67. IgG antibody staining was performed to serve as negative control. All are 40X. Scale bar is 50-μM. * indicates the lumen. Pooled data for Ki-67 index at the outflow vein of the <b>LV</b> and <b>C</b> transduced vessels at day 7 (<b>D7</b>), 14 (<b>D14</b>), and 21 (<b>D21</b>) is shown in (<b>B</b>). By day 7, there is a significant decrease in the mean Ki-67 index in the <b>LV</b> transduced vessels when compared to <b>C</b> at day 7 (P<0.01). By day 14, the mean Ki-67 index in the <b>LV</b> transduced vessels is significantly increased when compared to <b>C</b> (P<0.01). Each bar shows mean ± SEM of 4-6 animals per group. Two-way ANOVA followed by Student <i>t</i>-test with post hoc Bonferroni's correction was performed. Significant difference from control value was indicated by *<i>P</i><0.01.