Role of UCH-L1 in regulating cardiac fibroblast proliferation.

<p><b>A</b>. PDGF-induced UCH-L1 mRNA (<i>Left</i>) and protein (<i>Right</i>) expression in rat neonatal cardiac fibroblasts. Quiescent cells were treated with or without PDGF-AA (50 ng/ml), PGFD-BB (20 ng/ml), PDGF-CC (50 ng/ml), and PDGF-DD (50 ng/ml) for 24 h and subjected to Western blot analysis. n = 4, *p<0.05 vs SF controls. <b>B</b>. CCK-8, cell counting and Ki67 staining detected the role of UCH-L1 in regulating PDGF-induced rat neonatal cardiac fibroblast proliferation. n = 4, *p<0.05 vs. Ad-controls. Scale bar, 50 µm.