Localization of known human and bovine mutations affecting the EVC2 protein.

<p>The mutation found in chondrodysplastic Tyrolean Grey calves is shown in bold face. Previously reported mutations causing chondrodysplasia in cattle (shown in green) and Ellis-van Crefeld syndrome or Weyers acrofacial dysostosis (shown in red) in man are displayed with regard to their position and the cellular compartment of the protein <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094861#pone.0094861-Dorn1" target="_blank">[22]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094861#pone.0094861-Thompson1" target="_blank">[25]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094861#pone.0094861-DAsdia1" target="_blank">[28]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094861#pone.0094861-Ye1" target="_blank">[36]</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094861#pone.0094861-Tompson1" target="_blank">[38]</a>.