<p>Each panel (<b>A</b> to <b>D</b>) corresponds to the <i>E.coli</i> strain indicated at the top of the graph. Genomes containing m3C, undamaged G, and an approximately equimolar mixture of unmodified G/A/T/C bases at the site of inquiry (denoted as GATC) were used as controls. Genomes containing the lesions of interest were transfected into <i>E. coli</i> in triplicate. The percentage of G, A, T, and C at the lesion site reveals the mutagenicity of the lesions, with error bars representing one standard deviation. All mutagenesis data are summarized in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094716#pone.0094716.s001" target="_blank">Table S2 in File S1</a>.</p
Complete NotI, SfiI, XbaI and BlnI cleavage maps of Escherichia coli K-12 strain MG1655 were constru...
Complete NotI, SfiI, XbaI and BlnI cleavage maps of Escherichia coli K-12 strain MG1655 were constru...
Mismatch repair (MMR) is a major contributor to replication fidelity, but its impact varies with seq...
The mutagenic activity of MMS in E. coli depends on the susceptibility of DNA bases to methylation a...
To improve heterologous protein expression and growth of laboratory strains of Escherichia Coli, cre...
The mutagenic activity of MMS in E. coli depends on the susceptibility of DNA bases to methylation a...
<p>(A) Functional map of the Mu genome packaged within a phage particle, showing position of inserte...
<p>(A) Schematic representation of the transgene measuring NHEJ activity. A GFP gene lacking the ATG...
<p>H<sub>2</sub>O<sub>2</sub>-induced mutagenesis was measured in <i>mutS<sup>+</sup></i> (<b>A</b>)...
Escherichia coli has a correction system which removes mismatched bases from DNA1. Mutants (dam) whi...
Our goal is to construct an improved Escherichia coli to serve both as a better model organism and a...
<p>In the <i>y</i> axis, mutation frequencies; in the <i>x</i> axis, numbers of the serial passages ...
DNA adenine methylation by DNA adenine methyltransferase (Dam) in Escherichia coli plays an importan...
The damaging potential of ionizing radiation arises largely from the generation of clustered DNA dam...
The products of the mutD and mutL genes of Escherichia coli are involved in proofreading by DNA poly...
Complete NotI, SfiI, XbaI and BlnI cleavage maps of Escherichia coli K-12 strain MG1655 were constru...
Complete NotI, SfiI, XbaI and BlnI cleavage maps of Escherichia coli K-12 strain MG1655 were constru...
Mismatch repair (MMR) is a major contributor to replication fidelity, but its impact varies with seq...
The mutagenic activity of MMS in E. coli depends on the susceptibility of DNA bases to methylation a...
To improve heterologous protein expression and growth of laboratory strains of Escherichia Coli, cre...
The mutagenic activity of MMS in E. coli depends on the susceptibility of DNA bases to methylation a...
<p>(A) Functional map of the Mu genome packaged within a phage particle, showing position of inserte...
<p>(A) Schematic representation of the transgene measuring NHEJ activity. A GFP gene lacking the ATG...
<p>H<sub>2</sub>O<sub>2</sub>-induced mutagenesis was measured in <i>mutS<sup>+</sup></i> (<b>A</b>)...
Escherichia coli has a correction system which removes mismatched bases from DNA1. Mutants (dam) whi...
Our goal is to construct an improved Escherichia coli to serve both as a better model organism and a...
<p>In the <i>y</i> axis, mutation frequencies; in the <i>x</i> axis, numbers of the serial passages ...
DNA adenine methylation by DNA adenine methyltransferase (Dam) in Escherichia coli plays an importan...
The damaging potential of ionizing radiation arises largely from the generation of clustered DNA dam...
The products of the mutD and mutL genes of Escherichia coli are involved in proofreading by DNA poly...
Complete NotI, SfiI, XbaI and BlnI cleavage maps of Escherichia coli K-12 strain MG1655 were constru...
Complete NotI, SfiI, XbaI and BlnI cleavage maps of Escherichia coli K-12 strain MG1655 were constru...
Mismatch repair (MMR) is a major contributor to replication fidelity, but its impact varies with seq...