Chronic hypoxia induces a decrease in right ventricular ejection fraction.

<p>Right ventricular ejection fraction (EF) measured by MRI at 4 and 8 weeks. The following groups are compared: normoxia on normal chow diet (N/Cu+), normoxia on copper depleted diet (N/Cu), hypoxia on normal chow diet (H/Cu+) and hypoxia on copper depleted diet (H/Cu-). (b) Right ventricular end systolic volumes in cm³ and (c) right ventricular end diastolic volumes in cm³. (n = 6) (d) Griffonia simplicifolia 1 (GS-1)-stain on representative right ventricular free wall paraffin sections. (e) Quantification of GS-1 stain, expressed as relative vessel number. (f) Real-time PCR analysis of transcript abundance for cardiac stress marker genes in right ventricles at 8 weeks. (n = 3) *P<0.05 (mean ± s.e.m.).