Human corneal cells respond to TLR stimulation by producing cytokines.
- Radhika Susarla (552590)
- Lei Liu (5074)
- Elizabeth A. Walker (209779)
- Iwona J. Bujalska (332183)
- Jawaher Alsalem (552591)
- Geraint P. Williams (552592)
- Sreekanth Sreekantam (552593)
- Angela E. Taylor (552594)
- Mohammad Tallouzi (552595)
- H. Susan Southworth (552596)
- Philip I. Murray (552597)
- Graham R. Wallace (552598)
- Saaeha Rauz (552599)
Publication date
April 2014
DOIAbstract
<p>Multiplex bead ELISA analysis (Plex-30) of cytokine production in response to TLR 1–9 stimulation for 16 hours is shown. Cytokines analysed included: IL-1β, IL-1Rα, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12(p70), IL-13, IL-15, IL-17, Eotaxin, Basic FGF, G-CSF, GM-CSF, IFN-γ, CXCL-10, CCL2, CCL3, CCL4, PDGF-BB, CCL5, TNF-α, VEGF. Induction of a range of cytokines and chemokines was seen after TLR 3 challenge (CCL2, CCL3, CCL4, CCL5, CXCL10, IL1, IFNγ and IFNβ). Values = Mean+SE, n = 3, Statistical analysis was carried using One-way ANOVA and comparisons were drawn with untreated control Vs TLR stimulated cells. * p<0.05, ** p<0.01, *** p<0.001.</p
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