Tumorigenicity assay in nude mice.

<p>(A) Nude mice were subcutaneously injected in the right flank with control cells, SH3GL2 (+) stable transfected cells, miR-330 (−) stable transfected cells and SH3GL2 (+) & anti-miR-330 stable transfected cells. (B) A sample tumor from representative group at 42 days post-injection was shown. (C) Tumor growth curve in nude mice. After subcutaneous implantation, tumor volume was measured every 5 days in mm³ (<i>n = </i>5). *<i>P<</i>0.05 vs. control group, <i>^#P<</i>0.05 vs. SH3GL2 (+) group, <i>^▴P<</i>0.05 vs. miR-330 (−) group. (D) Numbers of survived mice for 60 days (<i>n = </i>15).