<p>The cytoskeleton and connection to ECM by integrins determine and regulate airway diameter through double inverse regulation of ASMA and SMMHC2 by stretch and agonist stimulation. Notice that without constriction (left), changes in protein levels are relative to their values at T0, whereas during constriction (right), changes in protein levels in the static condition are compared to their levels during dynamic conditions.</p
Respiratory symptoms are largely caused by obstruction of the airways. In asthma, airway narrowing m...
. Airway narrowing and internal structural constraints. J. Appl. Physiol. 88: 527-533, 2000.-A comp...
Airway smooth muscle (ASM) regulates flow resistance in the airways of the lung. Dysfunction of the ...
Recent reports suggest that tidal stretches do not cause significant and sustainable dilation of con...
<p>Effects of Ptm on the cross-bridge forming contractile proteins α-smooth muscle actin (ASMA, ∼42 ...
Many types of smooth muscle, including airway smooth muscle (ASM), are capable of generating maximal...
<p>Effects of static and dynamic Ptm on β-actin (act, ∼42 KDa) (<b>A</b> and <b>B</b>) and α-tubulin...
The ability of airway smooth muscle to alter its stiffness and contractility in response to mechanic...
Stress and strain are omnipresent in the lung due to constant lung volume fluctuation associated wit...
<p>Tissue stretch is transmitted to alveolar myofibroblasts directly by mechanoreceptors (integrins)...
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Techn...
Airway hyperresponsiveness (AHR) is a hallmark of asthma where constriction of airway smooth muscle ...
Asthma is characterized by structural changes in the airways - airway remodelling. These changes inc...
<p>Western blots are shown for integrin-β1 (Int, ∼140 KDa) and its phosphorylated form (ph-Int) (A a...
Abstract—Airway smoothmuscle cells exhibit stiffening during contractile activation. This stiffening...
Respiratory symptoms are largely caused by obstruction of the airways. In asthma, airway narrowing m...
. Airway narrowing and internal structural constraints. J. Appl. Physiol. 88: 527-533, 2000.-A comp...
Airway smooth muscle (ASM) regulates flow resistance in the airways of the lung. Dysfunction of the ...
Recent reports suggest that tidal stretches do not cause significant and sustainable dilation of con...
<p>Effects of Ptm on the cross-bridge forming contractile proteins α-smooth muscle actin (ASMA, ∼42 ...
Many types of smooth muscle, including airway smooth muscle (ASM), are capable of generating maximal...
<p>Effects of static and dynamic Ptm on β-actin (act, ∼42 KDa) (<b>A</b> and <b>B</b>) and α-tubulin...
The ability of airway smooth muscle to alter its stiffness and contractility in response to mechanic...
Stress and strain are omnipresent in the lung due to constant lung volume fluctuation associated wit...
<p>Tissue stretch is transmitted to alveolar myofibroblasts directly by mechanoreceptors (integrins)...
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Techn...
Airway hyperresponsiveness (AHR) is a hallmark of asthma where constriction of airway smooth muscle ...
Asthma is characterized by structural changes in the airways - airway remodelling. These changes inc...
<p>Western blots are shown for integrin-β1 (Int, ∼140 KDa) and its phosphorylated form (ph-Int) (A a...
Abstract—Airway smoothmuscle cells exhibit stiffening during contractile activation. This stiffening...
Respiratory symptoms are largely caused by obstruction of the airways. In asthma, airway narrowing m...
. Airway narrowing and internal structural constraints. J. Appl. Physiol. 88: 527-533, 2000.-A comp...
Airway smooth muscle (ASM) regulates flow resistance in the airways of the lung. Dysfunction of the ...