Complement activation during OM.

<p>Concentrations of C3, C3a, and C5a in the middle ear lavage fluid samples (A) and serum samples (B) from WT mice infected with a combination of IAV and Spn or either pathogen alone. Results are the mean concentrations (± SEM) in the middle ear lavage and serum samples from 5 mice from two separate experiments. *<i>P</i><0.05 for the comparison of the combined infection with each single pathogen alone. #, <i>P</i><0.05 for the comparison of mice infected with Spn alone with IAV alone.