Different structurally-defined neurons participate in different numbers of two and three edge motifs.

<p>This figure shows (for the rewired ring lattice with and ) histograms of the number of positive (A) and negative (B) feedback reciprocal connections for excitatory neurons; two types of negative feedback node-referenced three-synapse motif count histograms for excitatory neurons (C) and (D); and the all-excitation positive feedback motif count distribution for excitatory neurons (E). This data illustrates that although Class E2 neurons participate in as many positive feedback connections as E1 neurons, Class E2 excitatory neurons also participate in significantly fewer inhibition-inducing connections than Classes E1 and E3, and than E neurons in the random network. The notation indicates that the motif is one where a reference neuron () sends synaptic input to an excitatory neuron, which also sends synaptic input to the reference neuron. Notation of the form indicates that the motif is one where a reference neuron receives input from a synapse with an inhibitory neuron, which receives input from a synapse with an excitatory neuron, which also sends synaptic input to the reference neuron.