<p>*the mutant efficiency was calculated by mutant colonies/total single cell colonies.</p
Single-Cell AnalysisInternational audienceMutations have been investigated for more than a century b...
Background—Evolution depends on mutations: rare errors in the transmission of genetic information. E...
The rate of mutation refers to the probability that a unit length of DNA (generally a base pair) mut...
<p>Colony number and mutation rate obtained by error-prone PCR mediated mutagenesis.</p
a<p>: Counted only the founders where progeny was analyzed by both methods.</p>b<p>: Calculated assu...
a<p>Number of colonies with mutant octarepeats/total colonies screened; percentage in the parenthesi...
<p>Lysogenization efficiencies (calculated as Cm<sup>R</sup> cells/infected cells×100) of the mutant...
<p>Colony number and mutation rate obtained by hydroxyl amine mediated mutagenesis.</p
We describe how mutant yield data (mutants per cell treated) can be used both to compare the mutagen...
a<p>Data are means ± SD from three independent experiments for genetic manipulations.</p>b<p><i>ccpN...
<p>The total number of clones isolated, analyzed and containing the RE site modified are indicated f...
<p>(A) Enrichment of GFP<sup>+</sup> cells after hygromycin selection. Scale bar = 50 µm. (B) ZFN-dr...
Empirical knowledge of the fitness effects of mutations is important for understanding many evolutio...
Mutations have been investigated for more than a century but remain difficult to observe directly in...
<p>(A) Viability of all CA mutant clones at 35°C (this excludes nonsense mutations, duplicates, fram...
Single-Cell AnalysisInternational audienceMutations have been investigated for more than a century b...
Background—Evolution depends on mutations: rare errors in the transmission of genetic information. E...
The rate of mutation refers to the probability that a unit length of DNA (generally a base pair) mut...
<p>Colony number and mutation rate obtained by error-prone PCR mediated mutagenesis.</p
a<p>: Counted only the founders where progeny was analyzed by both methods.</p>b<p>: Calculated assu...
a<p>Number of colonies with mutant octarepeats/total colonies screened; percentage in the parenthesi...
<p>Lysogenization efficiencies (calculated as Cm<sup>R</sup> cells/infected cells×100) of the mutant...
<p>Colony number and mutation rate obtained by hydroxyl amine mediated mutagenesis.</p
We describe how mutant yield data (mutants per cell treated) can be used both to compare the mutagen...
a<p>Data are means ± SD from three independent experiments for genetic manipulations.</p>b<p><i>ccpN...
<p>The total number of clones isolated, analyzed and containing the RE site modified are indicated f...
<p>(A) Enrichment of GFP<sup>+</sup> cells after hygromycin selection. Scale bar = 50 µm. (B) ZFN-dr...
Empirical knowledge of the fitness effects of mutations is important for understanding many evolutio...
Mutations have been investigated for more than a century but remain difficult to observe directly in...
<p>(A) Viability of all CA mutant clones at 35°C (this excludes nonsense mutations, duplicates, fram...
Single-Cell AnalysisInternational audienceMutations have been investigated for more than a century b...
Background—Evolution depends on mutations: rare errors in the transmission of genetic information. E...
The rate of mutation refers to the probability that a unit length of DNA (generally a base pair) mut...
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