Genome-wide profiles of DNA:RNA hybrids in revealed similar enrichment of rDNA, retrotransposons and telomeres in wild type and mutants.

<p>DRIP-chip chromosome plot of DNA:RNA hybrids in wild type, <i>rnh1</i><b><i>Δ</i></b><i>rnh201</i><b><i>Δ</i></b>, <i>hpr1</i><b><i>Δ</i></b> and <i>sen1-1</i> at chromosome XII. The average of two replicates per strain is shown. Bars indicate ORFs (grey), rDNA (purple), retrotransposons (green) or genes associated with an antisense transcript (red) <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004288#pgen.1004288-Yassour1" target="_blank">[51]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004288#pgen.1004288-Xu1" target="_blank">[54]</a>). Grey boxes delineate telomeric repeat regions. Y-axis indicates relative occupancy of DNA:RNA hybrids. X-axis indicates chromosomal coordinates. P indicates probability of observing a number of enriched features below what was observed (P>0.99997).