Uncoupling of glomerular IgA and disease progression in transplanted <i>aly/aly</i> mice was independent of IgA-IgG IC formation and deposition.

<p>To further assess underlying mechanisms in the lack of the disease progression of IgAN in <i>aly/aly</i> mice, BM cells from a different line of poor-prognosis IgAN prone (line B) were transplanted in both mice. Although the serum levels of IgA-IgG IC were variable, some of the transplanted <i>aly/aly</i> mice (n = 5) showed similar amounts of IC (>2.5) to B6 mice (n = 5) (a). These selected <i>aly/aly</i> mice showed clear glomerular deposition of not only IgA but also IgG at 24 w, as seen in B6 mice (b). However, the progression of proteinuria and glomerular lesions was absent (c). This was associated with lack of F4/80 positive macrophages and CD4⁺ T cells (d). Data are presented as mean ± SD.