<p><i>Ifnar</i><sup>−/−</sup>, CD11c or LysM Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup>, and Cre<sup>−</sup><i>Ifnar</i><sup>f/f</sup> mice (<i>n</i> = 13 for each group) were infected with 10<sup>2</sup> PFU of WNV. Forty-eight hours later serum was collected and cytokines were analyzed by bioplex assay. Mean (pg/ml) and standard deviations (SD) are shown and <i>P</i> values are compared to Cre<sup>−</sup><i>Ifnar</i><sup>f/f</sup> mice. Data are pooled from four independent experiments. Ns, indicates results that are not statistically different compared to infected Cre<sup>−</sup><i>Ifnar</i><sup>f/f</sup> mice.</p
<p>Mice were inoculated with 10<sup>2</sup> PFU of WNV by footpad injection and sacrificed at the in...
<p>C57BL/6 mice showed significantly increased (A) TNFα (<i>P</i><0.0001, Mann-Whitney), (B) IL-1β (...
<p><b>A–C</b>. WT, <i>Ifnar</i><sup>−/−</sup>, <i>Mavs</i><sup>−/−</sup>, or <i>Mavs</i><sup>−/−</su...
<p>CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i><sup>−/−</sup> mice were treated ...
<p><b>A–G</b>. Viral burden in peripheral and CNS tissues after WNV infection. Eight- to ten-week-ol...
<p>CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i><sup>−/−</sup> mice were treated ...
<p>WT, <i>Irf3<sup>−/−</sup>×Irf7<sup>−/−</sup></i> DKO, <i>Irf3<sup>−/−</sup>×Irf5<sup>−/−</sup>×Ir...
<p><b>A–C</b>. Histological analysis of the (<b>A</b>) liver, (<b>B</b>) spleen, (<b>C</b>) LN, and ...
<p>Serum was collected from wild-type (<b>A-F</b>), <i>Ifnar1</i><sup>-/-</sup> (<b>G-L</b>), <i>Ifn...
<p><b>A</b>. Eight- to ten-week-old CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i>...
<p><b>A</b>. Survival of eight- to ten-week-old mice after inoculation with 10<sup>2</sup> PFU of WN...
<div><p>(A, B) Mice were inoculated with 10<sup>2</sup> PFU of WNV by footpad injection and euthaniz...
<p>Mice were infected with IAV i.n. and BALF fluids harvested at the indicated time points and asses...
<p>Serum was collected from WT and <i>db/db</i> mice at indicated days after infection. Levels of ch...
<p>TNF (A), IL-12 (B), IL-6 (C) and IFN-γ (D) were measured in the serum of congenic <i>Ity</i> (n =...
<p>Mice were inoculated with 10<sup>2</sup> PFU of WNV by footpad injection and sacrificed at the in...
<p>C57BL/6 mice showed significantly increased (A) TNFα (<i>P</i><0.0001, Mann-Whitney), (B) IL-1β (...
<p><b>A–C</b>. WT, <i>Ifnar</i><sup>−/−</sup>, <i>Mavs</i><sup>−/−</sup>, or <i>Mavs</i><sup>−/−</su...
<p>CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i><sup>−/−</sup> mice were treated ...
<p><b>A–G</b>. Viral burden in peripheral and CNS tissues after WNV infection. Eight- to ten-week-ol...
<p>CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i><sup>−/−</sup> mice were treated ...
<p>WT, <i>Irf3<sup>−/−</sup>×Irf7<sup>−/−</sup></i> DKO, <i>Irf3<sup>−/−</sup>×Irf5<sup>−/−</sup>×Ir...
<p><b>A–C</b>. Histological analysis of the (<b>A</b>) liver, (<b>B</b>) spleen, (<b>C</b>) LN, and ...
<p>Serum was collected from wild-type (<b>A-F</b>), <i>Ifnar1</i><sup>-/-</sup> (<b>G-L</b>), <i>Ifn...
<p><b>A</b>. Eight- to ten-week-old CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i>...
<p><b>A</b>. Survival of eight- to ten-week-old mice after inoculation with 10<sup>2</sup> PFU of WN...
<div><p>(A, B) Mice were inoculated with 10<sup>2</sup> PFU of WNV by footpad injection and euthaniz...
<p>Mice were infected with IAV i.n. and BALF fluids harvested at the indicated time points and asses...
<p>Serum was collected from WT and <i>db/db</i> mice at indicated days after infection. Levels of ch...
<p>TNF (A), IL-12 (B), IL-6 (C) and IFN-γ (D) were measured in the serum of congenic <i>Ity</i> (n =...
<p>Mice were inoculated with 10<sup>2</sup> PFU of WNV by footpad injection and sacrificed at the in...
<p>C57BL/6 mice showed significantly increased (A) TNFα (<i>P</i><0.0001, Mann-Whitney), (B) IL-1β (...
<p><b>A–C</b>. WT, <i>Ifnar</i><sup>−/−</sup>, <i>Mavs</i><sup>−/−</sup>, or <i>Mavs</i><sup>−/−</su...