<p>CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i><sup>−/−</sup> mice were treated with either anti-TNF-α blocking or isotype control MAbs (200 µg/mouse) one day prior to infection (<i>n</i> = 6 for each group). The mice were infected with 10<sup>2</sup> PFU of WNV. At 48 hours, serum was collected and AST, ALT and glucose levels were measured. Mean values ± SD are shown. <i>P</i> values are compared to isotype control treated samples for each group. Data are pooled from two independent experiments.</p
<p>Serum was collected from WT and <i>db/db</i> mice at indicated days after infection. Levels of ch...
<p><b>A</b>. Survival of eight- to ten-week-old mice after inoculation with 10<sup>2</sup> PFU of WN...
<p>(<b>A</b>) Mice received GFP<sup>+</sup> gDT-II cells prior to HSV-1 skin infection. IFM analysis...
<p>CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i><sup>−/−</sup> mice were treated ...
<p><b>A–G</b>. Viral burden in peripheral and CNS tissues after WNV infection. Eight- to ten-week-ol...
<p><i>Ifnar</i><sup>−/−</sup>, CD11c or LysM Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup>, and Cre<sup>...
<p><b>A</b>. Eight- to ten-week-old CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i>...
<p>Wild-type or <i>Irf7</i><sup><i>-/-</i></sup> mice were administered 500 μg of TIF-3C5 or isotype...
<p><b>A–C</b>. Histological analysis of the (<b>A</b>) liver, (<b>B</b>) spleen, (<b>C</b>) LN, and ...
<p>Serum was collected from wild-type (<b>A-F</b>), <i>Ifnar1</i><sup>-/-</sup> (<b>G-L</b>), <i>Ifn...
<p>(<b>A</b>) Blood urea nitrogen (BUN), (<b>B</b>) creatinine (Cr), (<b>C</b>) Alanine aminotransfe...
<p>Mice were inoculated with 10<sup>2</sup> PFU of WNV by footpad injection and sacrificed at the in...
<p>WT, <i>Irf3<sup>−/−</sup>×Irf7<sup>−/−</sup></i> DKO, <i>Irf3<sup>−/−</sup>×Irf5<sup>−/−</sup>×Ir...
<p>(A) Serum was collected from WT and <i>db/db</i> mice at indicated days after infection. IFN-α pr...
<p>C57BL/6 mice were treated daily with 8000 units of IFN α11 from −1 through +6 dpi with 5×10<sup>4...
<p>Serum was collected from WT and <i>db/db</i> mice at indicated days after infection. Levels of ch...
<p><b>A</b>. Survival of eight- to ten-week-old mice after inoculation with 10<sup>2</sup> PFU of WN...
<p>(<b>A</b>) Mice received GFP<sup>+</sup> gDT-II cells prior to HSV-1 skin infection. IFM analysis...
<p>CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i><sup>−/−</sup> mice were treated ...
<p><b>A–G</b>. Viral burden in peripheral and CNS tissues after WNV infection. Eight- to ten-week-ol...
<p><i>Ifnar</i><sup>−/−</sup>, CD11c or LysM Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup>, and Cre<sup>...
<p><b>A</b>. Eight- to ten-week-old CD11c Cre<sup>+</sup><i>Ifnar</i><sup>f/f</sup> and <i>Ifnar</i>...
<p>Wild-type or <i>Irf7</i><sup><i>-/-</i></sup> mice were administered 500 μg of TIF-3C5 or isotype...
<p><b>A–C</b>. Histological analysis of the (<b>A</b>) liver, (<b>B</b>) spleen, (<b>C</b>) LN, and ...
<p>Serum was collected from wild-type (<b>A-F</b>), <i>Ifnar1</i><sup>-/-</sup> (<b>G-L</b>), <i>Ifn...
<p>(<b>A</b>) Blood urea nitrogen (BUN), (<b>B</b>) creatinine (Cr), (<b>C</b>) Alanine aminotransfe...
<p>Mice were inoculated with 10<sup>2</sup> PFU of WNV by footpad injection and sacrificed at the in...
<p>WT, <i>Irf3<sup>−/−</sup>×Irf7<sup>−/−</sup></i> DKO, <i>Irf3<sup>−/−</sup>×Irf5<sup>−/−</sup>×Ir...
<p>(A) Serum was collected from WT and <i>db/db</i> mice at indicated days after infection. IFN-α pr...
<p>C57BL/6 mice were treated daily with 8000 units of IFN α11 from −1 through +6 dpi with 5×10<sup>4...
<p>Serum was collected from WT and <i>db/db</i> mice at indicated days after infection. Levels of ch...
<p><b>A</b>. Survival of eight- to ten-week-old mice after inoculation with 10<sup>2</sup> PFU of WN...
<p>(<b>A</b>) Mice received GFP<sup>+</sup> gDT-II cells prior to HSV-1 skin infection. IFM analysis...