Associations of CD8⁺ CTLs with survival in HER-2 negative (n = 291) and HER-2 positive (n = 41) cancers.

<p>In HER-2 negative breast cancers (n = 291), Kaplan Meier curves showed that positive CD8⁺ CTLs infiltrate status had significantly longer DFS than negative CD8⁺ CTLs infiltrate status (Log-rank test: P = 0.005; Fig. 4A). Furthermore, longer OS was also significantly associated with positive CD8⁺ CTLs infiltrate status (Log-rank test: P = 0.049; Fig. 4B). In HER-2 positive breast cancer (n = 41), however, no significant associations were showed between CD8⁺ CTLs infiltrate status and DFS (Log-rank test: P = 0.408; Fig. 4C), OS (Log-rank test: P = 0.155; Fig. 4D).