<p>Protein crystal structure [PDB∶2JIU] shown as cartoon, with sites G724, T725, L858 and L861 shown as spheres. Structural regions highlighted in yellow are kinase subdomain I and the activation loop. The structure image was generated using PyMOL <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003545#pcbi.1003545-Delano1" target="_blank">[75]</a>.</p
<p>(A) X-ray crystallographic resolved structures of E82Q (PDB ID: 6F0R) and E82A (PDB ID: 6F0N) mut...
<div><p>Schematic representation of the wild-type EGFR tyrosine kinase domain (cyan) bound to erloti...
<p>SMART (<a href="http://smart.embl-heidelberg.de/" target="_blank">http://smart.embl-heidelberg.de...
<p>(A) The histogram displays the proportions of mutation counts detected at each residue to the tot...
<p>(A) Crystal structure of EGFR extracellular domain (1ivo.pdb, chain A) <a href="http://www.ploson...
<p>(A) In-scale schematic representation of a PDGF-BB dimer with the location of the known PFBC-asso...
<div><p>(A) Space-filling representation of the wild-type kinase active site (cyan) with the viewer ...
Upper panel: cartoon representation of the protein with inhibitor S43 shown in sticks and zinc ion a...
(A) Model for ligand-induced homodimerization of EGFR. The inactive EGFR monomer forms a symmetric d...
<p>a) Structure showing an EGFR dimer in active conformation (based on[<a href="http://www.ploscompb...
<p>A The subdomains I, II, III and IV of both receptors are colored pink, orange, cyan and purple, r...
<p>The crystallographic structures of wild type KIT cytoplasmic region in the inactive auto-inhibite...
<p>The figure is taken from the crystal structure, PDB code: 3FCS (<i>27</i>). Domains I-EGF3 and I-...
<p>Renderings of the five hundred randomized structures used as initial structures in simulations af...
<div><p>(A) Mutations are limited to the first four exons (exons 18–21) of the tyrosine kinase (TK) ...
<p>(A) X-ray crystallographic resolved structures of E82Q (PDB ID: 6F0R) and E82A (PDB ID: 6F0N) mut...
<div><p>Schematic representation of the wild-type EGFR tyrosine kinase domain (cyan) bound to erloti...
<p>SMART (<a href="http://smart.embl-heidelberg.de/" target="_blank">http://smart.embl-heidelberg.de...
<p>(A) The histogram displays the proportions of mutation counts detected at each residue to the tot...
<p>(A) Crystal structure of EGFR extracellular domain (1ivo.pdb, chain A) <a href="http://www.ploson...
<p>(A) In-scale schematic representation of a PDGF-BB dimer with the location of the known PFBC-asso...
<div><p>(A) Space-filling representation of the wild-type kinase active site (cyan) with the viewer ...
Upper panel: cartoon representation of the protein with inhibitor S43 shown in sticks and zinc ion a...
(A) Model for ligand-induced homodimerization of EGFR. The inactive EGFR monomer forms a symmetric d...
<p>a) Structure showing an EGFR dimer in active conformation (based on[<a href="http://www.ploscompb...
<p>A The subdomains I, II, III and IV of both receptors are colored pink, orange, cyan and purple, r...
<p>The crystallographic structures of wild type KIT cytoplasmic region in the inactive auto-inhibite...
<p>The figure is taken from the crystal structure, PDB code: 3FCS (<i>27</i>). Domains I-EGF3 and I-...
<p>Renderings of the five hundred randomized structures used as initial structures in simulations af...
<div><p>(A) Mutations are limited to the first four exons (exons 18–21) of the tyrosine kinase (TK) ...
<p>(A) X-ray crystallographic resolved structures of E82Q (PDB ID: 6F0R) and E82A (PDB ID: 6F0N) mut...
<div><p>Schematic representation of the wild-type EGFR tyrosine kinase domain (cyan) bound to erloti...
<p>SMART (<a href="http://smart.embl-heidelberg.de/" target="_blank">http://smart.embl-heidelberg.de...