<i>In vitro</i> sensitivity of human and mouse ovarian epithelial carcinoma cells to anti-cancer treatment.

<p>Human (A, B) and murine (C–H) ovarian cancer cells were exposed to cisplatin, olaparib or vehicle for 7 days after which cell viability was measured using XTT reagent. Proportional viability was calculated by comparing the drugs with vehicle controls whose viability was assumed to be 100%. C. Panel of murine cell lines was selected based on <i>Brca1</i> status containing <i>Brca1</i>-deficient (striped bar) and –wild type lines (filled bars) maintaining similar <i>Brca1</i> expression as their tumors of origin (D). IC50 values for individual cancer cell lines are shown in the legends (A, B, E, G, parenthesis behind the cell line designation). Comparison of the IC50 for cisplatin (F) and olaparib (H) in wild type (<i>TgK18G_T121^tg/+/p53^Δ/Δ</i>; R5810T, R5838T) and mutant (<i>TgK18G_T121^tg/+/Brca1^Δ/Δ/p53^Δ/Δ</i>; 39647T, 60577T, 60580T, 82394T) murine cell lines shows significant difference between the genotypes (T-test, 333.7±54.1 vs 146.0±8.2, p<0.01 and 18.2±1.4 vs 10.4±1.2, p<0.05, respectively for drugs). The average and standard error is shown.