<p>The nuclei of the cells are stained in blue with DAPI. The PLA signals are detected with red filter. A) SLC38A6 interacts with Snap25 exhibiting proximity to the membrane. B) SLC38A6 interacts with Synaptotagmin, illustrating substantial proximity to the vesicular proteins. C) PLA control with no primary antibody incubation and hence no signal of interaction between proteins demonstrating successful PLA in the treated cells. D) Signals per cell were counted and represented here as histograms. Columns 1, 2, 3, 4 and 5 reveal interactions between Synaptotagmin-Synaptotagmin, Snap25-Snap25, Synaptotagmin-Snap25, SLC38A6-Synaptotagmin and SLC38A6-Snap25, respectively. Columns 1 and 2 exhibit quantification of PLA signals obtained by using di...
The detection of protein-protein interactions by imaging techniques often requires the overexpressio...
Proximity ligation assay (PLA) has become the assay of choice for demonstrating the proximity of a v...
he proximity ligation assay (PLA) is a sensitive and specific technique to visualize proteins, their...
In recent years, the ability to investigate proteins in cell cultures and tissue samples has expande...
Protein-protein interactions (PPI) by homo-, hetero- or oligo-merization in the cellular environment...
International audienceCombining immunological and molecular biological methods, the antibody-based p...
The aggregation of alpha-synuclein (alpha Syn) is the pathological hallmark of Parkinson's disease, ...
The cells building up the human body is in constant communication with each other. This communicatio...
<p>The aggregation of alpha-synuclein (αSyn) is the pathological hallmark of Parkinson’s disease, de...
<p>(<b>A</b>) Flag (dark green) bound to a neutravidin (yellow) with Cy3B-conjugated (red) oligonucl...
Summary: Improper or aberrant protein-protein interactions can lead to severe human diseases includi...
<p>According to our proposed model, SLC38A6 is located at the membrane of synapse and is shown as a ...
With a growing and ageing population, neurodegenerative diseases like Alzheimer’s disease (AD) are g...
Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of prote...
Fluorescence was visualized by confocal microscopy in human Control 1 fibroblasts (a) and human neur...
The detection of protein-protein interactions by imaging techniques often requires the overexpressio...
Proximity ligation assay (PLA) has become the assay of choice for demonstrating the proximity of a v...
he proximity ligation assay (PLA) is a sensitive and specific technique to visualize proteins, their...
In recent years, the ability to investigate proteins in cell cultures and tissue samples has expande...
Protein-protein interactions (PPI) by homo-, hetero- or oligo-merization in the cellular environment...
International audienceCombining immunological and molecular biological methods, the antibody-based p...
The aggregation of alpha-synuclein (alpha Syn) is the pathological hallmark of Parkinson's disease, ...
The cells building up the human body is in constant communication with each other. This communicatio...
<p>The aggregation of alpha-synuclein (αSyn) is the pathological hallmark of Parkinson’s disease, de...
<p>(<b>A</b>) Flag (dark green) bound to a neutravidin (yellow) with Cy3B-conjugated (red) oligonucl...
Summary: Improper or aberrant protein-protein interactions can lead to severe human diseases includi...
<p>According to our proposed model, SLC38A6 is located at the membrane of synapse and is shown as a ...
With a growing and ageing population, neurodegenerative diseases like Alzheimer’s disease (AD) are g...
Proteins are fundamental structural, enzymatic and regulatory components of cells. Analysis of prote...
Fluorescence was visualized by confocal microscopy in human Control 1 fibroblasts (a) and human neur...
The detection of protein-protein interactions by imaging techniques often requires the overexpressio...
Proximity ligation assay (PLA) has become the assay of choice for demonstrating the proximity of a v...
he proximity ligation assay (PLA) is a sensitive and specific technique to visualize proteins, their...