Schematic diagram of relative location of SLC38A6 in the cell.

<p>According to our proposed model, SLC38A6 is located at the membrane of synapse and is shown as a trans-membrane protein in dark blue. It interacts with the well-known membrane protein Snap25 present at the synaptic junction/cleft and is represented here as light blue circles. The vesicular protein Synaptotagmin is shown in green and is interacting with SLC38A6 when the vesicles are in close proximity to the membrane, prior to the release of neurotransmitters. Some of the relevant interactions, as recorded by PLA signals, are shown by red double arrows.