The effect of PDGF-inhibitors in fPCLS on viability, gene expression of fibrosis markers and collagen 1 protein expression.

<p>The effect of PDGF-inhibitors imatinib (n = 4), sorafenib (n = 4) and sunitinib (n = 4) on the viability (A), on the gene expression of fibrosis markers <i>Hsp47</i>, <i>αSma</i> and <i>Pcol1A1</i> (B) and on the collagen 1 protein expression (pictures are from a representative experiment) (C) of fibrotic PCLS from livers from BDL rats incubated for 48 hours. Error bars represent SEM. Significant decrease: *p<0.05 vs 48h, #p<0.05 vs 0 hours, +p<0.05 vs 24 hours.